In the last 60 years, milk, meat, and egg worldwide consumption per capita increased 2-, 3-, and 5-fold, respectively. In the same period, several studies have reported a drop of semen quality and an increased incidence of cryptorchidism, hypospadias, and some hormone-related cancers (testicular, prostate, breast, endometrial cancer) in humans. A possible reason for these disruptions is increased exposure to exogenous hormones in food of animal origin. Hormones in food are considered to affect the endocrine system and cell signaling and thus disrupt homeostasis in the consumers. Since food safety assurance is a part of the veterinary service, the risk assessment of hormones in food as potential disruptive compounds is a significant challenge. Numerous cohort and epidemiologic studies and meta-analyses have been performed with respect to find an association between the consumption of food of animal origin and particular health disorders. Additionally, several studies in animal models have been performed to explain the mechanisms of disruptive effects of exogenous hormones. Since contradictory results have been reported, there is no general conclusion about the disruptive effects of exogenous hormones. Further experiments on animals in which long-term treatment with exogenous hormones is performed and further comprehensive endocrinological, toxicological, and human epidemiological studies are needed to confirm or deny the role of exogenous hormones in human health disorders. Moreover, long-term exposure to a combination of several exogenous compounds, such as environmental pollutants and dietary hormones and their additive effects, are also not well known and should be a topic for further studies.
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1. Ritchie H Roser M: Meat and seafood production and consumption. [https://ourworldindata.org/meat-and-seafood-production-consumption]
2. FAO: Feeding the world. [http://www.fao.org/3/i3107e/i3107e03.pdf]
3. Carlsen E Giwercman A Keiding N Skakkebeak N: Evidence for decreasing quality of semen during past 50 years. Brit Med J 1992 205:609–613.
4. Aho Koiv isto AM Tammela TL Auvinen A: Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970-1994. Environ Health Perspect 2000 108:463–465.
5. Carmichae l SL Shaw GM Nelson V Selvin S Torfs CP Curry CJ: Hypospadias in California: Trends and descriptive epidemiology. Epidemiology 2003 14:701–706.
6. Paulozzi LJ: International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect 1999 107:297–302.
7. Ganmaa D Sato A: The possible role of female sex hormones in milk from pregnant cows in the development of breast ovarian and corpus uteri cancers. Medical Hyptheses 2005 65:1028–1037.
8. Sharpe RM Skakkebeak NE: Are estrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993 341:1392–1395.
9. Courant F Antignac J Laille J Monteau F Andre F Le Bizec B: Exposure assesment of preburtal children to steroid endocrine disruptors. Determination of steroid hormones in milk egg and meat samples. J Agric Food Chem 2008 56:3176–3184.
10. Coady K Mathiessen P Zahner NM Staveley J Caldwell DJ Levine SL Gray jr LE Borgert CJ: Endocrine disruption: where are we with hazard and risk assessment? Peer J Preprints 2016 4:e2580v1.
11. CRL Guidance paper (7 December 2007): CRLs view on state of the art analytical methods for national residue control plans. [https://www.rivm.nl/bibliotheek/digitaaldepot/crlguidance2007.pdf]
12. US DHHS-FDA (Department of Health and Human Services – Food and Drug Administration): Guidance for industry. General principles for evaluating the human food safety of new animal drugs used in food-producing animals. [https://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/UCM052180.pdf]
13. Macrina AL Ott TL Roberts RF Kensinger RS: Estrone and estrone sulfate concentrations in milk and milk fractions. J Acad Nutr Dietet 2012 112:1088–1093.
14. Leon-Olea M Martyniuk CJ Orlando EF Ottinger MA Rosenfeld CS Wolstenholme JT Trudeau VL: Current concepts in neuroendocrine disruption. General and Comparative Endocrinology 2014 203:158–173.
15. Fortier A Trasler J: Potential epigenetic consequences associated with assisted reproduction. In: Epigenitc and human reproduction. Heidelberg Germany: Springer; 2011 3–18.
16. Drobnis EZ Nangia AK: Male reproductive functions disrupted by pharmacological agents. Advan Experiment Med Biol 2017 1034–24.
17. Andersson AM Skakkebaek NE: Exposure to exogenous estrogens in food: possible impact on human development and health. Eur J Endocrinol 1999 140:477–485.
18. Schug TT Janesick A Blumberg B Heindel JJ: Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Molec Biol 2011 127:204–215.
19. Torfadottir JE Steingrimsdottir L Mucci L Aspelund T Kasperzyk JL Olafsson O Fall K Tryggvadottir L Harris TB Launer L Jonsson E Tulinius H Stampfer M Adami HO Gudnason V Valdimarsdottir UA: Milk intake in early life and risk of advanced prostate cancer. Am J Epidemiol 2012 175:144–153.
20. Key TJA Pike MC: The dose-effect relationship between ‘unopposed’ estrogens and mitotic rate: its general role in explaning and predicting endometrial cancer risk. Brit JCancer 1988 57:205–212.
21. Dickson RB Lippman ME: Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr Rev 1987 8:29–43.
22. Braekevelt EB Lau P Tague B Popovic S Tittlemier SA. Effect of cooking on concentrations of β-estradiol and metabolites in model matrices and beef. J Agric Food Chem 2011 59:915–920.
23. Snoj T Zuzek MC Cebulj-Kadunc N Majdic G: Short communication: Heat treatment and souring do not affect milk estrone and 17b-estradiol concentrations. J Dairy Sci 2018 101:61–65.
24. Hartmann S Lacorn M Steinhart H: Natural occurrence of steroid hormones in food. Food Chem 1998 62:7–20.
25. Zhou H Qin LQ Ma DF Wang Y Wang PY: Uterotrophic effects of cow milk in immature ovariectomized Sprague-Dawley rats. Environment Health Prevent Med 2010 15:162–168.
26. Gaiani R Chiesa F Mattioli M Nanneti G Galeati G: Androstenedione and testosterone concentrations in plasma and milk of cow throughout pregnancy. J Reprod Fertil 1984 70:55–90.
27. Heap RB Hamon M: Oestrone sulphate in milk as an indicator of a viable conceptus in cows. Br Vet J 135:355–363.
28. Malekinejad H Scherpenisse P Bergerff AA: Naturaly occurring estrogens in processed milk and in raw milk (from gestated cows). J Agric Food Chem 2006 54:9785–9791.
29. Pape-Zambito DA Magliaro AL Kensinger RS: 17b-estradiol and estrone concentrations in plasma and milk during bovine pregnancy. J Dairy Sci 2008 91:127–135.
30. Farlow DW Xu X Veenstra TD: Comparison of estrone and 17b-estradiol levels in commercial goat and cow milk. J Dairy Sci 2012 95:1699–1708.
31. Macdonald IA Bokkenheuser VD Winter J McLernon AM Mosbach EH: Degradation of steroids in the human gut. J Lip Res 1983 24:675–700.
32. Parodi PW: Impact of cow’s milk estrogen on cancer risk. Int Dairy J 2012 22:3–14.
33. US DHHS-FDA (Department of Health and Human Services – Food and Drug Administration): Steroid hormone implants used for growth in food-producing animals. [https://www.fda.gov/animal-veterinary/product-safety-information/steroid-hormone-implants-used-growth-food-producing-animals]
34. US DHHS-FDA (Department of Health and Human Services – Food and Drug Administration): Report on the Food and Drug Administration’s review of the Safety of recombinant bovine somatotropin. [https://www.fda.gov/animal-veterinary/product-safety-information/report-food-and-drug-administrations-review-safety-recombinant-bovine-somatotropin]
35. Dohoo IR DesCoteaux L Leslie K Fredeen A Shewfelt W Preston A Dowling P: A meta-analysis review of the effects of recombinant bovine somatotropin. Can J Vet Res 2003 67:252–264.
36. Maldonado-Cerceles AB Minguez-Alacon L Mendiola J Vioque J Jorgensen N Arense Gonzalo JJ Tores-Cantero AM Chavarro J: Meat intake in relation to semen quality and reproductive hormone levels among young men in Spain. Br J Nutr 2018 121:1–10.
37. Afeiche MC Williams PL Gaskins AJ Mendiola J Jorgensen N Swan SH Chavarro JE: Meat intake and reproductive parameters among young men. Epidemiology 2014 25:323–330.
38. Xia W Chiu YH Williams PL Gaskins AJ Toth TL Tanrikut C Hauser R Chavarro JE: Men’s meat intake and treatment outcomes among couples undergoing assisted reproduction. Fertil Steril 2015 104:972–979.
39. Swan SH Liu F Overstreet JW Brazil C Skakkebeak NE: Semen quality of fertile US males in relation to their mothers’ beef consumption during pregnancy. Hum Reprod 2007 22:1497–1502.
40. Afeiche MC Bridges ND Williams PL Gaskins AJ Tanrikut C Petrozza JC Hauser R Chavarro JE: Dairy intake and semen quality among men attending a fertility clinic. Fertil Steril 2014 101:1280–1287.
41. Afeiche M Williams PL Mendiola J Gaskins AJ Jorgensen N Swan SH Chavarro JE: Dairy food intake in relation to semen quality and reproductive hormone levels among physically active men. Hum Reprod 2013 28:2265–2275.
42. Dizavi A Eini-Zinab H Hosseini J Omidvar N Hosseini MA: Relationship between dairy product consumption and oligospermia; a case-control study. Men Health J 2018 2:1–7.
43. Xia W Chiu YH Afeiche MC Williams PL Ford JB Tanrikut C Souter I Hauser R Chavarro JE: Impact of men’s dairy intake on assisted reproductive technology outcomes among couples attending a fertility clinic. Andrology 2016 4:277–283.
44. Cross AJ Leitzmann MF Gail MH Hollenbeck AR Schatzkin A Sinha R: A prospective study of red and processed meat intake in relation to cancer risk. PLoS Med 2007 4:e325.
45. Lijinsky W: N-Nitroso compounds in the diet. Mutat Res 1999 443:129–138.
46. Ohgaki H Hasegawa H Kato T Suenaga M Sato S Takayama S Suqimura T: Carcinogenicities in mice and rats of IQ MeIQ and MeIQx. Princess Takamatsu Symp 1985 16:97–105.
47. Bandera EV Kushi LH Moore DF Gifkins DM McCullough ML: Consumption of animal foods and endometrial cancer risk: a systematic literature review and meta-analysis. Cancer Causes Control 200718:967–988.
48. Dagnelie PC Schuurman AG Goldbohm RA Van den Brandt PA: Diet anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies. BJU Int 2004 93:1139–1150.
49. WHO: Agents classfied by the IARC monographs volumes 1-123. [https://monographs.iarc.fr/agents-classified-by-the-iarc/]
50. Dong JY Zhang L He K Qin LQ: Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies. Breast Cancer Res Treat 2011 127:23–31.
51. Zang J Shen M Du S Chen T Zou S: The association between dairy intake and breast cancer in Western and Asian populations: a systematic review and meta-analysis. J Breast Cancer 2015 18 313–322.
52. Moorman PG Terry PD: Consumption of dairy products and the risk of breast cancer: a review of the literature. Am J of Clin Nutr 2004 80:5–14.
53. Missmer SA Smith-Warner SA Spiegelman D Yaun SS Adami HO Beeson WL van den Brandt PA Fraser GE Freudenheim JL Goldbohm RA Graham S Kushi LH Miller AB Potter JD Rohan TE Speizer FE Toniolo P Willett WC Wolk A Zeleniuch-Jacquotte A Hunter DJ: Meat and dairy food consumption and breast camcer: a pooled analysis of cohort studies. Int J Epidemiol 2002 31:78–85.
54. Davies TW Palmer CR Ruja E Lipscombe JM: Adolescent milk dairy product and fruit consumption and testicular cancer. Brit J Cancer 1996 74:657–660.
55. Aune D Navarro Rosenblatt DA Chan DS Vieira AR Vieira R Greenwood DC Vatten LJ Norat T: Dairy products calcium and prostate cancer risk: a systematic review and meta-analysis of cohort studies. Am J Clin Nutr 2015 101:87–117.
56. Andersson SO Baron J Wolk A Lindgren C Bergström R Adami HO: Early life risk factors for prostate cancer: a population-based case-control study in Sweden. Cancer Epidemiol Biomark Prevent 1995 4:187–192.
57. Aune D De Stefani E Ronco AL Boffetta P Deneo-Pellegrini H Acosta G Mendilaharsu M: Egg consumption and the risk of cancer: a multisite case-control study in Uruguay. Asian Pac J Cancer Prev 2009 10:869–876.
58. Zamora-Ros R Cayssials V Cleries R Redondo ML Sanchez MJ Rodriguez-Barranco M5 Sanchez-Cruz JJ Mokoroa O Gil L Amiano P Navarro C Chirlaque MD Huerta JM Barricarte A Ardanaz E Moreno-Iribas C Agudo A: Moderate egg consumption and all-cause and specific-cause mortality in the Spanish European Prospective into Cancer and Nutrition (EPIC-Spain) study. Eur J Nutr 2018 doi: 10.1007/s00394-018-1754-6.
59. Fernandez E Chatenoud L La Vecchia C Negri E Franceschi S: Fish consumption and cancer risk. Am J Clin Nutr 1999 70:85–90.
60. Santarelli RL Vendeuvre JC Naud N Tache S Gueraud F Viau M Genot C Corpet DE Pierre FHF: Meat processing ant colon carcinogenesis: cooked nitrite-treated and oxidized high-heme cured meat promoted mucin-depleted foci in rats. Cancer Prev Res (Phila Pa) 2010 3:852–864.
61. Parnaud G Peiffer G Tache S Corpet DE: Effect of meat (beef chicken and bacon) on rat colon carcinogenesis. Nutr Cancer 1998 32:165–173.
62. Ganmaa D Tezuka H Enkhmaa D Hoshi K Sato A: Commercial cows’ milk has uterotrophic activity on the uteri of young ovariectomized rats and immature rats. Int J Cancer 2005 118: 2363–2365.
63. Li XM Ganmaa D Qin LQ Sato A: Testing potential effects of environmental endocrine disruptors in cow milk on reproductive index in female rats. Biomed Environ Sci 2005 18:307–313.
64. Ganmaa D Qin LQ Wang PY Tezuka H Teramoto S Sato A: A two-generation reproduction study to assess the effects of cows’ milk on reproductive development in male and female rats. Fertil Steril 2004 82:1106–1114.
65. Grgurevič N Koračin J Majdič G Snoj T: Effect of dietary estrogens from bovine milk on blood hormone levels and reproductive organs in mice. J Dairy Sci 2016 99:6005–6013.
66. Qin LQ Xu JY Wang PY Ganmaa D Li J Wang J Kaneko T Hoshi K Shirai T Sato A: Low-fat milk promotes the development of 712-dimethylbenz(A)anthracene (DMBA)-induced mammary tumors in rats. Int J Cancer 2004 110:491–496.
67. Genkinger JM Koushik A: Meat consumption and cancer risk. PLoS Med 2007 4:e345.
68. Panth N Gavarkovs A Tamez M Mattei J: The Influence of diet on fertility and the implications for public health nutrition in the United States. Front Public Health 2018 6:211.
69. Davoodi H Esmaeili S Mortazavian AM: Effects of milk and milk products consumption on cancer: a review. Compr Rev Food Sci Food Saf 2013 12:249–264.
70. Snoj T Majdič G: Estrogens in consumer milk: is there a risk to human reproductive health? Eur J Endocrinol 2018 179:275–286.
71. Malekinejad H Rezabakhsh A: Hormones in dairy foods and their impact on public ealth - A narrative review article. Iran J Public Health. 2015 44:742–758.
72. Keum N Lee DH Marchand N Oh H Liu H Aune D Greenwood DC Giovannucci EL: Egg intake and cancers of the breast ovary and prostate: a dose-response meta-analysis of prospective observational studies. Br J Nutr 2015 114:1099–1107.
73. Snoj T Majdič G Kobal S Žužek M Čebulj-Kadunc N: Estrone 17b-estradiol and progesterone concentrations in processed milk with different fat content. Veterinarski Glasnik 2017 71(1):35-43. doi: 10.2298/VETGL170324006S