Phytochemicals with potential effects in metabolic syndrome prevention and therapy

Open access


Metabolic syndrome represents a clustering of risk factors related to an elevated danger of cardiovascular diseases and type 2. diabetes. The high incidence of obesity, the key risk factor in metabolic syndrome, and the lack of safe pharmaceutical agents have fuelled an increase in research related to anti-metabolic syndrome drugs. Phytochemicals have biological properties such as antioxidant, modulation of detoxification enzymes, stimulation of the immune system, reduction of platelet aggregation and modulation of hormone metabolism. These compounds include vitamins, comprising of vitamin C, D and E, flavonoids, phenolic acids, omega-3 and omega-6 fatty acids. Furthermore, the latest discoveries and studies on the molecular mechanism of these phytochemicals suggested their potential positive effect in the prevention and treatment of obesity and other risk factors associated with the metabolic syndrome. They should be incorporated in food ingredients, dietary supplements, or drug preparations. The main focus of this article is to review the available information on various aspects of phytochemicals, with special reference to their effectiveness in risk reduction of the metabolic syndrome and obesity-related diseases.

Abate N (2000) Journal of Diabetes and Its Complications 14: 154-174.

Akitunde AA, Akinwusi PO (2011) Clinical Medicine&Research, 9: 26-31.

Awika JM, Rooney LW (2004) Phytochemistry, 65: 1199-1221.

Balkau B, Valensi P, Eschwege E, Slama G (2007) Diabetes&Metabolism 33: 405-413.

Bastard JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A, Robert JJ, Capeau J, Hainque B (2002) Journal of Clinica Endokrinology & Metabolism 87: 2084-2089.

Basu A, Du M, Wilkinson M, Simmons B, Wu M, Betts NM, Fu DX, Lyons TJ (2010) Nutrition Research 30: 462-469.

Bates CJ, Walmsley CM, Prentice A, Steven F (1998) Journal of Hypertensive 16: 925-932.

Bays HE (2009) American Journal of Medicine 122: 26-37.

Benmohammed K, Nguyen MT, Khensal S, Valensi P, Lezzar A (2011) Diabetes and Metabolism 37: 291-297.

Bischhof SC (2008) Current Opinion in Clinical Nutrition & Metabolic Care 11: 733-40.

Blake GJ, Otvos JD, Rifai N, Ridker PM (2002) Circulation 106. 1930-1937.

Blondeau N, Schneider SM (2006) Nutrition clnique et metabolisme 20: 68-72.

Bray GA (2007) The Metabolic Syndrome and Obesity. Humana Press, New Jersey.

Brown AA, Hu FB (2001) American Journal of Clinical Nurition 73: 673-686.

Caroll S, Cooke CB, Buterly RJ (2000) Medicine & Science in Sports & Exercise 32: 2079-86.

Carpentier YA, Portois L, Malaisse WJ (2006) American Journal of Clinical Nutrition 83: 1499-504.

Cederroth CR, Nef (2009) Molecular and Cellular Endocrinology 304: 30-42.

Ceriello A, Giugliano D, Quatro A (1991) Clinical Science 81: 739-742.

Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F (1997) International Journal of Obesity and Related Metabolic Disorders 21: 637-643.

Dakshinamurti K, Lal KJ (1996) World Review of Nutrition Dietetics 69: 40-73.

De Busk RM (2000) Current Aterosclerosis Reports 2: 508-514.

Devaraj S, Leonard S, Traber MG, Jialal I (2008) Free Radical Biology and Medicine 44: 1203-1208.

Diamant M, Lamb HJ, Van de Ree MA, Endert EL, Groeneveld Y, Bots ML, Kostense PJ, Radder JK (2005) The Journal of Clinical Endocrinology & Metabolism 90: 1495-501.

Donohoe CL, Doyle SL, Reynolds JV (2011) Diabetology and Metabolic syndrome 3: 1-13.

Donora E, Capaldo B, Perin PC, DelPrato S, De Matia G, Frittitta L, Frontoni S, Leonoetti f, Luzi L, Marchesini G, Marini MA, Natali A, Paolisso G (2008) Nutrition, Metabolism and Cardiovascular Diseases 18: 624-631.

Draznin B, Sussmann K, Kao M, Lewis D, Sherman N (1987) Journal of Biology and Chemistry 262. 14385-14388.

Eaton SB, Konner MJ (1997) European Journal of Clinical Nutrition 51: 207-216.

Eaton-Evans J (2005). In: Caballero B (Ed) Encyclopedia of Human Nutrition, Vol 4 (pp 311-318) Elsevier Academic Press, Oxford.

Fabryova Ľ (2007) Via Practika 4: 13-18. Fan ZA (2007) Current Cardiology reviews 3: 232-239.

Feldeisen SE, Trucker KL (2007) Applied Physiology, Nutrition and Metabolism 32: 46-60.

Ford AS, Mokdad AH, Giles WH, Brown DW (2003) Diabetes 52: 2346-2352.

Formiguera X, Canton A (2004) Best Practice and Research Clinical Gastroenterology 18: 1125-1146.

Galajda P, Mokaň M (2004) Diabetes a obezita 7: 39-49.

Galajda P, Mokaň M (2006) Diabetes a obezita 11: 73-79.

Galvano F, La Fauci L, Lazzarino G, Fogliano V, Ritieni A, Ciappellano S, Ciappelanno S, Battistini NC, Tavazzi B, Galvano G (2004) Journal of Nutrition Biochemistry 15: 2-11.

Grundy SM (2002) Circulation 106: 2526-2529.

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Spertus JA, Costa F (2005) Circulation 112: 2735-2752.

Gutin B, Litaker M, Islam S, Manos T, Smith C, Treiber F (1996) American Journal of Clinical Nutrition 63: 287-292.

Hainer V, Kunešova M (1997) Obezita - Etiopatogeneze, diagnostika a terapie. Galen, Praha. Hideki H, Nagulesparan M, Klimeš I, Clark R, Sasaki H, Aronoff SL, Vasquez B, Rubenstein A, Unger RH (1982) Journal of Clinical Endocrinology and Metabolism 54: 217-222.

Horn L, McCoin M, Penny M, Burke F, Carson JS, Champagne CM, Karvally W, Sikand G (2008) Journal of the American Dietetic Association 108: 287-331.

Houston MC (2005) Nutraceuticals and Hypertension 47: 396-449.

Hsu CL, Huang SL, Yeng C (2006) Journal of Agriculture and Food Chemistry 54: 4191-4197.

Hsu CL, Wu CH, Huang SL, Yen GC (2009) Jounal of Agriculture Food and Chemistry 57: 425-431.

Hsu CL, Yen GC (2008) Molecular Nutrition & Food Research 52: 53-61.

Hvang JT, Park IJ, Shin JT, Lee YK, Lee SK, Baik HW, Ha J, Park OJ (2005) Biochemical and Biophysical Research Communications 338: 694-699.

Ikeda I, Kobayashi M, Hamada T (2003) Journal of Agriculture and Food Chemistry 51: 7303-7307.

Kelley DE, Makaň M, Mandarino LJ (1992) Diabetes 41: 698-706.

Kelley DS, Fedor D (2009) Current Opinion in Clinical Nutrition and Metabolic Care 12: 138-146.

Klimeš I (1998). In: Vozar J, Krese A, Klimeš I Diabetes mellitus, (pp70-77), Slovak Academic Press, Bratislava Koba K, Abe K, Ikeda I, Sugano M (1992) Bioscience, Biotechnology and Biochemstry 56: 1420-1423.

Korhonen S, Hippelainen M, Vanhala M, Heinonen S, Niskanen L (2003) Fertility and Sterility 79: 1327-34.

Krahulec B (2008). In: Mokaň M a kol., (eds) Diabetes mellitus a vybrane metabolicke ochorenia (pp 756-767). P+M, Martin.

Krahulec B, Klimeš I, Fabryova Ľ (2009) Algoritmy liečby 2: 3-13.

Krauss RM (1995) American Journal of Cardiology 75: 53-57.

Kumar A, Singh V (2010) Vascular Health and Risk Management 6: 665-669.

Kuntic V, Pejic N, Ivkovic B (2007) Journal of Pharmaceutical and Biomedical Analysis 43: 718-721.

Lacueva CA, Remon AM, Llorach R, Sarda UM, Khan N, Blanch GC, Ros ZR, Ribalta RM, Raventos RML (2011). In: Rosa LA, Parilla EA, Aguilar GAG Fruit and Vegetable Phytochemicals, Vol 1 (53-88). Wiley-Blackwel, USA.

Lam KSL, Xu A, Wat NMS., Tso AVK, Ip MSM (2000) International Congress Series 1262: 542-545.

Lao CD, Ruffin MT, Normolle D., Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE (2006) BMC Complementary and Alternative Medicine 6: 10-20.

Liu RH (2007) Journal of Cereal Science 46: 207-219.

Luceri C, Guglielmi F, Lodovici L, Giannini L, Messerini L, Dolara P (2004) Scandinavian Journal of Gastroenterology 39: 1128-33.

Macho A, Sancho R, Minassi A, Appendino G, Lawen A, Munoz E (2003) Free Radical Research 37: 611-609.

Majerčak I (2006) Via Practica 6: 298-300.

Matsui T, Tanaka T, Tamura S, Toshima A, Tamaya K, Miyata Y, Tanaka K, Matsumoto K (2007) Journal of Agriculture and Food Chemistry 55: 99-105.

McCarron DA (1989) Kidney International 35: 717-736.

Monteiro R, Azevedo I (2010) Mediators of Inflammation: 1-10.

Mori TA, Burke V, Puddey IB, Shaw JE, Beilin LJ (2004) Journal of Hypertension 22: 983-990.

Moris MC (1994) Journal of Cardiovascular Risk 1: 21-30.

Moure A, Cruz JM, Franco D, Dominguez JM, Sineiro J, Dominguez H, Nuńez MJ Parajo JC (2001) Food Chemistry 72: 145-171.

Naczk M, Shadiky F (2004) Journal of Chromatography A 1054: 95-11.

NATIONAL CHOLESTEROL ADUCATION PROGRAM (NCEP) EXPERT PANEL ON DETECTION, EVALUATION, AND TREATMENT OF HIGH BLOOD CHOLESTEROL IN ADULTS (ADULT TREATMENT PANEL III): Third Report of the National Cholesterol Aducation Program (NCEP) ExpertPanel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) final report. Circulation 106: 3143-3421.

Nevaz MA. Nawal NNA (1999) Clinical and Experimental Hypertension 21: 1297-1313.

Perez MR, Gomez MG (2011) Endocrinologia Y Nutricion 58: 360-369.

Perez-Vizcaino F, Duarte J, Audriantshitohaina R (2006) Free Radical Research 40: 1054-1065.

Petersen KF, Shulman GI (2006) American Journal of Medicine 119: 10-16.

Potenza MV, Mechanick JI (2009) Nutrition and Clinical Practice 24: 560-577.

Prasain JK, Carlson SH, Wyss JM (2010) Maturitas 66: 163-164.

Procopiou M, Phillippe J (2005) Cerebrovascular Diseases 20: 2-8.

Rabe K, Lehrke M, Parhofer KG, Broedl UC (2008) Molecular Medicine 14: 741-751.

Rask-Madsen C, Domingues H, Ihlemann N (2003) Circulation 108: 1815-1821.

Reaven GM (1993) Annual Review of Medicine 44: 121-131.

Ritchie SA, Conell JMC (2007) Nutrition, Metabolism & Cardiovascular Diseases 17: 319-326.

Russo C, Olivieri O, Girelly D, Faccini G, Zenari ML, Lombardi S, Corrocher R (1998) Journal of Hypertension 16: 1267-1271.

Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagai M, Matsuzawa Y, Funahashi T (2004) Circulation Journal 68: 975-981.

Rytting K (2005) Food, diet and obesity. CRC Press LLC, Holandsko.

Salamone LM, Fuerst T, Visser M, Kern M, Lang T, Dockrel M, Cauley J, Nevitt M, Tylavsky F, Lohman TG (2000) Journal of Applied Physiology 89: 345-352.

Salonen JT, Salonen R, Ihananen M, Parviainen M, Seppanen R, Kantola M, Seppanen K, Rauramaa R (1998) American Journal of Clinical Nutrition 48: 1226-1232.

Scott MG (2004) Journal of Clinica Endokrinology & Metabolism 89: 2595-2600.

Shilpa NB, Tucker KL (2011) Clinica Chimica Acta 412: 1494-1914.

Sninčak M (2006) Arteriova hypertenzia v staršom veku. TypoPress, Košice.

Stalicas CD (2007) Journal of Separation Science 30: 3268-3295.

Stevenson DE, Hurst RD (2007) Cellular and Molecular Life Sciences 64: 2900-2916.

Strazzulo P, Barbatto A, Siani A, Cappuccio FP, Versiero M, Schiattarella P, Russo O, Avallone S, della Valle E, Farinaro E (2008) Metabolism Clinical and Experimental 57: 355-361.

Subramanian N, Venkatesh P, Ganguli S, Sinkar VP (1999) Journal of Agriculture and Food Chemistry 47: 2571-2578.

Surh YJ (2002) Food Chemistry and Toxicology 40: 1091-1097.

Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS (2001) Mutation Research, 480: 243-268.

Svačina Š, Bretšnajdrova A (2008) Klinicka dietologie. Grada, Praha.

Taesun P, Yunyung K (2011) Antiobesity Drug Discovery and Development 1: 14-20.

Tai K, Need AG, Horowitz M, Chapman IM (2008) Nutrition 24: 279-285.

Tan CB (2007) Cardiovascular and Haematological Disorgers-Drug Targets 7: 99-108.

Thielecke F, Boschmann M (2009) Phytochemistry 70: 11-23.

Tkač I (2006) Cardiology 15: 305-310.

Tsuda T, Ueno Y, Yoshikawa T, Kojo H, Osawa T (2006) Biochemical Pharmacology 71: 1184-1197.

Van de Vijver LPL, Van den Bosch LMC, Van den Brandt PA, Goldbohm RA (2009) European journal of Clinical Nutrition 63: 31-38.

Van Horn L, McCoin M, Kris-Etherton PM, Burke F, Carson JA, Champagne CM, Karmally W, Sikand G (2008) Journal of the American Dietetic Association 108: 287-331.

Wen Z, Kilalle S, McGettigan P, Feely J (1996) Irish Journal of Medical Sciences 165: 210-212.

Acta Chimica Slovaca

The Journal of Slovak University of Technology in Bratislava

Journal Information


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 117 117 9
PDF Downloads 31 31 1