Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

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Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencement of therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.

Suplementacija antioksidansima i serumski lipidi kod bolesnika s Gravesovom bolešću: Učinak na LDL-kolesterol

SAŽETAK Promatran je učinak suplementacije fiksnom kombinacijom antioksidansa (beta-karoten, selen, vitamini C i E) na koncentracije serumskih lipida, u odnosu na brzinu postizanja eutiroze, u bolesnika s novo otkrivenom Gravesovom bolešću. Bolesnici su randomizirani u dvije skupine. Test skupinu sačinjavali su bolesnici koji su liječeni metimazolom (tiamazolom), te su dodatno dobivali antioksidanse, a kontrolnu skupinu bolesnici koji su uzimali samo metimazol (tiamazol). Koncentracije ukupnog i HDL-kolesterola u serumu porasle su tijekom terapije kod bolesnika iz obje skupine (p < 0.05), no nisu se međusobno značajno razlikovale 60 dana nakon početka terapije. Kod bolesnika test skupine, koncentracija LDL-kolesterola značajno se povećala (p < 0.005) i bila je značajno različita od one u kontrolnoj skupini (p < 0.005) 60 dana nakon početka liječenja. Zbog značajnog porasta koncentracije LDL-kolesterola kod bolesnika s Gravesovom bolešću koji su dodatno uzimali antioksidanse potrebna su daljnja istraživanja u cilju pojašnjenja opisanih promjena.

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