Original article. Influence of +Gz exposure on serum biochemical and hematological parameters

Open access


Background: Exposure to high +Gz provoke a unique physiological stress and various potential harmful effects in humans. Despite the importance of monitoring physical alterations related to +Gz exposure, there have been only a few studies concerning the physical status of human centrifuge trainees.

Objective: We investigated alterations in serum biochemical and complete blood count parameters occurring in subjects exposed to high +Gz.

Methods: One hundred fifty eight flight-naive subjects (group A), who had never experienced flight or centrifuge training, and 80 experienced jet fighter pilots (group B) were exposed to +6Gz and +7.3Gz, respectively. Blood samples were obtained before and immediately after the centrifuge runs.

Results: In group A, creatine phosphokinase (CPK) was increased from a mean of 136.56±17.87 IU/L pre-run to 236.33±23.71 IU/L post-run, a significant 73.1% increase. In 26 of 158 (16.5%) group A subjects, CPK was elevated over 400 IU/L, with a maximum of 1904 IU/L. Δ CPK of group A (99.77±16.94 IU/L) was significantly greater than that of group B (0.53±5.67 IU/L). In addition, Δvalues of total protein, white blood cell count, red blood cell count, hemoglobin, and hematocrit of group A were significantly greater than those of group B.

Conclusion: We demonstrated that the extent of post-centrifuge CPK elevation and hemoconcentration was significantly greater in flight-naive subjects than in experienced jet fight pilots. Our data raise the possibility that the level of experience in flight and centrifuge training can affect the extent of +Gz-induced alterations in blood constituents.

1. Forster EM. Heart rate response of aircrew during recovery from gradual onset rate +Gz exposures. Aviat Space Environ Med. 1994; 65:55-9.

2. Mills FJ, Marks V. Human endocrine responses to acceleration stress. Aviat Space Environ Med. 1982; 53:537-40.

3. Norsk P. Gravitational stress and volume regulation. Clin Physiol. 1992; 12:505-26.

4. Ossard G, Clere JM, Kerguelen M, Melchior F, Seylaz J. Response of human cerebral blood flow to +Gz accelerations. J Appl Physiol. 1994; 76:2114-8.

5. Tachibana S, Akamatsu T, Nakamura A, Yagura S. Serious arrhythmias coinciding with alteration of consciousness in aircrew during +Gz stress. Aviat Space Environ Med. 1994; 65:60-6.

6. Gillingham KK, Fosdick JP. High-G training for fighter aircrew. Aviat Space Environ Med. 1988; 59: 12-9.

7. Burns JW, Laughlin MH, Witt WM, Young JT, Ellis JP, Jr. Pathophysiologic effects of acceleration stress in the miniature swine. Aviat Space Environ Med. 1983; 54:881-93.

8. Gillingham KK, Crump PP. Changes in clinical cardiologic measurements associated with high +Gz stress. Aviat Space Environ Med. 1976; 47:726-33.

9. Noakes TD. Effect of exercise on serum enzyme activities in humans. Sports Med. 1987; 4:245-67.

10. Stansbie D, Aston JP, Dallimore NS, Williams HM, Willis N. Effect of exercise on plasma pyruvate kinase and creatine kinase activity. Clin Chim Acta. 1983; 132: 127-32.

11. McLellan CP, Lovell DI, Gass GC. Creatine kinase and endocrine responses of elite players pre, during, and post rugby league match play. J Strength Cond Res. 2010; 24:2908-19.

12. McLellan CP, Lovell DI, Gass GC. Biochemical and endocrine responses to impact and collision during elite Rugby League match play. J Strength Cond Res. 2011; 25:1553-62.

13. Kenney K, Landau ME, Gonzalez RS, Hundertmark J, O’Brien K, Campbell WW. Serum creatine kinase after exercise: drawing the line between physiological response and exertional rhabdomyolysis. Muscle Nerve. 2012; 45:356-62.

14. Kim HJ, Lee YH, Kim CK. Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race. Eur J Appl Physiol. 2009; 105:765-70.

15. Dembinski A, Warzecha Z, Ceranowicz P, Stachura J, Tomaszewska R, Konturek SJ, et al. Pancreatic damage and regeneration in the course of ischemia-reperfusion induced pancreatitis in rats. J Physiol Pharmacol. 2001; 52:221-35.

16. Hoffmann TF, Leiderer R, Waldner H, Arbogast S, Messmer K. Ischemia reperfusion of the pancreas: a new in vivo model for acute pancreatitis in rats. Res Exp Med (Berl). 1995; 195:125-44.

17. Gullo L, Cavicchi L, Tomassetti P, Spagnolo C, Freyrie A, D’Addato M. Effects of ischemia on the human pancreas. Gastroenterology. 1996; 111:1033-8.

18. Laughlin MH, Burns JW, Parnell MJ. Regional distribution of cardiac output in unanesthetized baboons during +Gz stress with and without an anti- G suit. Aviat Space Environ Med. 1982; 53:133-41.

19. Joehl RJ, Rose RC, Nahrwold DL. Norepinephrine stimulates amylase release from pancreatic acini. J Surg Res. 1983; 34:543-9.

20. Burton RR, Storm WF, Johnson LW, Leverett SD, Jr. Stress responses of pilots flying high-performance aircraft during aerial combat maneuvers. Aviat Space Environ Med. 1977; 48:301-7.

21. Van Beaumont W, Greenleaf JE, Young HL, Juhos L. Plasma volume and blood constituent shifts during +Gz acceleration after bedrest with exercise conditioning. Aerosp Med. 1974; 45:425-30.

22. Greenleaf JE, Brock PJ, Haines RF, Rositano SA, Montgomery LD, Keil LC. Effect of hypovolemia, infusion, and oral rehydration on plasma electrolytes, ADH, renin activity, and +Gz tolerance. Aviat Space Environ Med. 1977; 48:693-700.

23. Hurford WE, Hochachka PW, Schneider RC, Guyton GP, Stanek KS, Zapol DG, et al. Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal. J Appl Physiol. 1996; 80:298-306.

24. Hurford WE, Hong SK, Park YS, Ahn DW, Shiraki K, Mohri M, et al. Splenic contraction during breath-hold diving in the Korean ama. J Appl Physiol. 1990; 69: 932-6.

25. Anderson RS, Rogers EB. Hematocrit and erythrocyte volume determinations in the goat as related to spleen behavior. Am J Physiol. 1957; 188:178-88.

26. Froelich JW, Strauss HW, Moore RH, McKusick KA. Redistribution of visceral blood volume in upright exercise in healthy volunteers. J Nucl Med. 1988; 29: 1714-8.

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